Senescence and immortality in hepatocellular carcinoma

Senescence and immortality in hepatocellular carcinoma.

Cellular senescence is a process leading to terminal growth arrest with characteristic morphological features. This process is mediated by telomere-dependent, oncogene-induced and ROS-induced pathways, but persistent DNA damage is the most common cause. Senescence arrest is mediated by p16(INK4a)- and p21(Cip1)-dependent pathways both leading to retinoblastoma protein (pRb) activation. p53 play...

Disruptive chemicals, senescence and immortality.

Carcinogenesis is thought to be a multistep process, with clonal evolution playing a central role in the process. Clonal evolution involves the repeated 'selection and succession' of rare variant cells that acquire a growth advantage over the remaining cell population through the acquisition of 'driver mutations' enabling a selective advantage in a particular micro-environment. Clonal selection...

Hepatocellular Carcinoma in Sheep

Hepatocellular carcinoma in a sheep

At necropsy of a five-year-old sheep, a pear shaped, lobular yellow-brownish mass measuring about 12 ×15 × 20 cm was found to involve the right hepatic lobe. Microscopic examination revealed two trabecularand solid patterns of neoplastic hepatocytes. In solid pattern, there were numerous tumoral giant cells thatcontain one or more large hyperchromatic bizarre-shaped nuclei scattered among clust...

Pro-senescence therapy for hepatocellular carcinoma

(HCC) is one of the most frequent human malignancies with poor prognosis. Due to the current limitations of therapeutic options, there is a pressing need to elucidate the molecular mechanisms underlying human hepatocarcinogenesis and to identify novel targets for systemic therapy. It has recently been shown that Deleted in Liver Cancer 1 (DLC1), encoding a RhoGAP (Rho GTPase activating protein)...